Effects PrEP

Yes Pre-exposure prophylaxis has both short term and long term side effects
SHORT TERM SIDE EFFECTS:
Short term side effects are often the most noticeable, though usually occur at the commencement of your medication and often for a short period.
Examples of short term side effects: nausea, headaches, diarrhea and general body weakness
These usually subside within a few weeks of consistent taking of PrEP.
Some PrEP. Users have reported that, taking the tablet during or soon after a meal can reduce the side effects.
If you are concerned for any other reason, you should talk to your healthcare provider.
LONGER TERM SIDE EFFECTS:
While much less common, there are some side effects that might impact you as you take PrEP over an extended period.
Side effect 1: Renal dysfunction.
In very rare cases taking PrEP can affect your liver and kidneys (renal) health, this is why a renal function test is administered before PrEP initiation and terminally. If you notice your skin or the white parts of your eyes turning yellow, dark ‘tea-colored’ urine, light colored stools or loss of appetite for several days or longer you should mention this to your prescribing doctor immediately
Side effect 2: Bone density.
In some rare cases, PrEP may cause some loss of bone density, which can lead to a higher chance of bone fractures. Should this occur, you can cease taking PrEP and your bone density will recover over time.
Part of the PrEP program ensures that you visit your PrEP prescriber regularly for repeat HIV and STI testing, as well as regularly checking bone density, kidney and liver function.